Sclerostin Antibody Reverses the Severe Sublesional Bone Loss in Rats After Chronic Spinal Cord Injury.
RatSpinal cord injuryComplete transectionWistarMalen = Sham n = 10, spinal cord injury plus vehicle n = 11, spinal…Subcutaneous25 mg/kg per weekStarted 12 weeks after spinal cord transection
Model: Complete spinal cord transection (chronic motor-complete spinal cord injury), with laminectomy-only sham
At 20 weeks after injury, vehicle-treated transected rats had lower bone mineral density at the distal femur, proximal tibia and lumbar spine (about -22, -15 and -9 per cent versus sham), reduced trabecular bone volume (-37.2 per cent) and connectivity (-53.2 per cent), reduced cortical thickness (…
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