Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa beta-related pathway in rats.
RatHaemorrhage/shockUnspecifiedSprague-Dawleyn = 165 adult rats in total; n = 5 per group for behavioural, E…Oral gavage25, 50 and 100 mg/kg; 50 mg/kg was the most effective dosePre-treatment one day before induction of intracerebral haemorrhage
Model: Collagenase type VII induced intracerebral haemorrhage, 0.5 U in 2 microlitres saline injected into the right basal ganglia at 0.4 microlitres/min (coordinates 0.2 mm anterior, 3 mm right lateral to bregma, 6 mm ventral)
Theaflavin pre-treatment improved behavioural performance, reduced Evans blue extravasation, brain water content in the injured hemisphere and reactive oxygen species, lowered IL-1beta, IL-18, TNF-alpha, interferon gamma, TGF-beta and CXCL1, preserved Nissl bodies and reduced TUNEL-positive cells,…
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