The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma.
MouseHaemorrhage/shockControlledC57BL/6MaleIntravenous bolus100 nmol/kg (high dose) or 10 nmol/kg (low dose)At start of resuscitation, after 1 h of haemorrhage
Model: Blast wave-induced blunt chest trauma (TxT) followed by 1 h haemorrhagic shock and 4 h resuscitation
High dose AP39 attenuated systemic inflammation and reduced pulmonary iNOS and IkappaB alpha expression, but in the combined trauma plus haemorrhagic shock group it produced the lowest mean arterial pressure, highest norepinephrine requirement and higher mortality. Low dose AP39 had no haemodynamic…
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