Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-kappaB in a murine endotoxemia model.

Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-kappaB in a murine endotoxemia model.

Model: Mechanical ventilation (6 mL/kg or 10 mL/kg tidal volume) for 8 h with or without endotoxaemia, causing ventilator-induced diaphragm dysfunction

Mechanical ventilation with endotoxaemia aggravated diaphragmatic injury, proteolysis, oxidative loading, autophagy and apoptosis and reduced muscle fibre size. This endotoxin-exacerbated ventilator-induced diaphragm dysfunction was attenuated by pharmacologic NF-kappaB inhibition or by TLR4 defici…

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