Optogenetic Inhibition of CGRPalpha Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain.
MouseOtherTransgenic mice selectively expressing archaerhodopsin-3 (Arch) in CGRPalpha neuronsMale and femaleTransdermal light activation for optogenetic inhibition; peripheral (local) administration for receptor blockadeApplied after injury, assessed longitudinally from acute to chronic time points
Model: Skin-muscle incision (inflammatory or incisional pain) and spared nerve injury (neuropathic pain)
After spared nerve injury, brief Arch activation reversed chronic mechanical, cold and heat hypersensitivity, alleviated spontaneous pain and reversed sensitised mechanical currents in afferent somata. Arch inhibition did not alter incision-induced hypersensitivity; instead, incision-induced mechan…
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