Inhibition of the cyclophilin A-CD147 interaction attenuates right ventricular injury and dysfunction after acute pulmonary embolism in rats.
RatOtherSprague-DawleyMale
Model: Acute pulmonary embolism induced by intravenous injection of microspheres, causing right ventricular injury and dysfunction
Cyclophilin A and CD147 rose synchronously in right ventricular tissue after embolism, peaking at 24 h. Cyclosporine A reduced cyclophilin A levels and anti-CD147 abrogated the CD147 rise. Treatment with cyclosporine A, anti-CD147 or both attenuated the increases in right ventricular systolic press…
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