Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical.
RatBurnUnspecifiedPretreatment (for the conjugated diene experiments)
Model: Thermal (burn) injury to the skin of rats producing remote acute lung injury
Iron chelators, hydroxyl radical scavengers and vitamin E each gave significant protection from acute lung injury measured by lung vascular permeability and morphology. Conjugated dienes appeared sequentially in burned skin at 15 minutes, lung at 2 hours and plasma at 30 minutes and 3 hours, and th…
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