A novel Ca current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice.
MixedIschaemia-reperfusionCardiacC57BL/6Male12 to 24 mg/kg in mice; 50 to 200 microM in zebrafish; 200…Treatment given after myocardial infarction for 14 days
Model: Experimental myocardial infarction
ADTM at 12 to 24 mg/kg for 14 days significantly reduced myocardial infarct size and increased peri-infarct vessel density, and 24 mg/kg raised serum VEGF (P < 0.05). ADTM rescued chemical-induced vessel loss in zebrafish and increased VEGF in A7r5 cells, and at 200 microM inhibited L-type calcium…
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