The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
MouseTBIControlled cortical impactInbred C57BLMale
Model: Controlled cortical impact
Caspase-1 inhibition reduced pyroptosis in injured brain microvascular endothelial cells, limited blood-brain barrier leakage, brain oedema and tight junction protein loss, and improved neurological outcome after controlled cortical impact.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.