Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier.
RatTBIWeight-drop / impact-accelerationSprague-DawleyMaleHigh dose 20 micrograms in 20 microlitresAdministered after traumatic brain injury, with assessment 24 hours later
Model: Feeney free-falling weight-drop traumatic brain injury
High-dose recombinant human MANF increased the modified Garcia score and reduced brain water content and cerebral oedema volume, lowered blood-brain barrier permeability and reduced interleukin 1 beta and tumour necrosis factor alpha expression, with inhibition of P65 activation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.