Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Inbred C57BLIntranasal160 ng/kg1 hour after stroke in the acute neuroprotection arm and 24 hours after stroke…
Model: Focal ischaemic stroke (middle cerebral artery occlusion)
Early intranasal rPKM2 reduced infarct volume by more than 60 percent, while delayed rPKM2 increased angiogenic factor expression, neuroblast homing, angiogenesis, neurogenesis, local blood flow recovery and sensorimotor function; all beneficial effects were abolished by the STAT3 inhibitor BP-1-10…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.