Eliciting inflammation enables successful rehabilitative training in chronic spinal cord injury.
RatSpinal cord injuryHemisection / partialLewisFemaleSystemic injection8 weeks after injury (chronic phase)
Model: Chronic (8 weeks) dorsolateral quadrant section of the cervical spinal cord at C4
Low-dose systemic lipopolysaccharide improved the efficacy of rehabilitative training on forelimb reaching and grasping in chronically injured rats. The benefit depended on training intensity, with high-intensity training producing the largest improvement, and the combination restored original move…
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