Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male and female
Model: Permanent middle cerebral artery occlusion (neonatal ischaemic stroke)
PJ34 reduced lesion size by 78 per cent and CX3CR1-labelled microglial density by 46 per cent at 3 days in male but not female mice. At 8 days, M1-like Iba1/Cox-2 cells fell in PJ34-treated males in the amygdala, while M2-like Iba1/Arg-1 and transitional Arg-1/Cox-2 cells rose in treated females. p…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.