Effects of controlled abnormal joint movement on the molecular biological response in intra-articular tissues during the acute phase of anterior cruciate ligament injury in a rat model.
RatOtherWistarMalen = 84 rats randomised across four groups; tissue harvested at…Surgical, intra-articular nylon sutureAt the time of anterior cruciate ligament transection
Model: Complete midsubstance transection of the anterior cruciate ligament of the right knee
Both transection groups showed ligament cleavage, but the controlled abnormal movement group had a very small gap in the ligament stump with fibroblast proliferation around it. Relative to transection alone, controlled abnormal movement significantly lowered MMP-13 mRNA expression and the MMP-13 to…
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