Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization.

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization.

Model: Rat model of acute ischaemic stroke, with in vitro oxygen and glucose deprivation of primary microglia and a clinical cohort of 70 patients and 35 controls

Following acute ischaemic stroke, inflammatory cytokines rose while IL-4, IL-10 and miR-30d-5p fell in both patients and animal models. In vitro, suppression of autophagy reduced the oxygen and glucose deprivation-induced inflammatory response, and exosome treatment further suppressed inflammation…

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