Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice.
MouseRadiationC57Bl/6Femalen = n = 4 per group for cystometry and plasma measurements; n =…Continuous subcutaneous infusion via ALZET osmotic pump (model 1002) implanted at the lower mid-back50 to 400 micrograms per kg per day, with 400 micrograms pe…Started 7 weeks after irradiation
Model: Selective bladder irradiation at 10 Gy via laparotomy, producing chronic radiation cystitis with fibrosis, reduced compliance and contractility and overflow incontinence within 6 weeks
hRLX2 reversed radiation-induced bladder fibrosis, reduced collagen content, improved bladder wall architecture and increased bladder compliance, detrusor Cav1.2 expression and detrusor contractility. At 400 micrograms per kg per day the voiding pattern normalised with larger voided volumes and com…
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