Autologous and not allogeneic adipose-derived stem cells improve acute burn wound healing.
RatBurnContact / flameWistar (outbred)malen = 20 male Wistar rats in total; 3 animals and 6 wounds per he…Subcutaneous injection beneath the panniculus carnosus, either into the wound centre or at four corners 0.5 cm from the wound edge (250 microlitres per corner, 1 mL total)Immediately after debridement, 24 h after the burn
Model: Two identical circular full-thickness contact burn wounds (4 mm radius) made on the dorsum with a metal rod heated to 95 degrees C for 30 s, followed by punch debridement to the panniculus carnosus at 24 h
Autologous adipose-derived stem cells significantly accelerated closure of acute full-thickness burn wounds compared with medium-injected control and with allogeneic cells, reaching 99 to 100 per cent closure by day 15, whereas allogeneic cells did not differ from control. Injection at four corners…
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