PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome.
MouseRadiationCD2F1maleSubcutaneous0.3 mg/kg single dose for efficacy studies; 1.2 mg/kg singl…24 h before, 4 h after, or 24 h after total-body irradiation
Model: Cobalt-60 gamma total-body irradiation at lethal doses (haematopoietic acute radiation syndrome)
A single 0.3 mg/kg subcutaneous dose given 24 h before, 4 h after or 24 h after irradiation raised survival to 70 to 100 per cent after lethal irradiation, with pre-administration at minus 24 h giving significantly higher survival than dosing at 24 h after irradiation. Pretreated animals showed acc…
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