PRECLINICAL PUBLICATION · 2018

A cytokine network involving IL-36gamma, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Exogenous recombinant IL-23

PMID 29760082 ↗2018Reported benefit

A cytokine network involving IL-36gamma, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

MouseOther

Model: Murine model of acute intestinal (colonic) barrier damage and repair

IL-36R-deficient and IL-36gamma-deficient mice showed reduced IL-23, IL-22 and antimicrobial peptides and failed to recover; exogenous IL-23 rescued recovery and restored IL-22 and antimicrobial peptide expression.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.