FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1alpha Stabilization.
MouseWoundBALB/c (from MeSH indexing)male (from MeSH indexing)
Model: Cutaneous excisional skin wound
Acute hypoxia switched epidermal stem cells from quiescence to an activated state with higher viability and motility, mediated by HIF-1 signalling. Exogenous FG-4592 accelerated wound healing, shortened healing time and induced epidermal hyperplasia in vivo.
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