Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle-in-Vein Grafts.
RatOtherLewis (Rats, Inbred Lew)femaleSurgical implantation (nerve conduit)15 mm nerve guide bridging a 15 mm gapImmediately upon transection (acute repair) or after a delay of 45 days (delaye…
Model: Sciatic nerve transection with a critical 15 mm gap, reconstructed either immediately or after a 45-day delay
Regular and corrugated chitosan nerve guides supported functional recovery of distal plantar muscles similarly to each other and to a greater extent than muscle-in-vein grafts, but autologous nerve grafts gave the best regeneration. Compression stability was slightly increased for regular guides an…
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