Nanoencapsulation of Cyanidin-3-O-glucoside Enhances Protection Against UVB-Induced Epidermal Damage through Regulation of p53-Mediated Apoptosis in Mice.
MouseRadiationKunming (KM)femaleTopical application to dorsal skinNano-C3G at 125, 250 and 500 micromolar; free C3G at 500 mi…Applied after dehairing and before or around UVB exposure (stated as treated af…
Model: Acute skin photodamage induced by exposing dehaired dorsal skin to 2 J/cm2 of UVB
Nano-C3G reduced UVB-induced lipid peroxidation, malondialdehyde and 8-hydroxy-2'-deoxyguanosine, downregulated p53, Bax and caspases 3 and 9, and improved skin appearance, moisture, histology and apoptotic index. Nano-C3G was more effective than free C3G at the same 500 micromolar concentration.
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