Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats.
RatChemical/toxinSprague-DawleyMaleInjection (route not stated in abstract)LY293558 15 mg/kg; caramiphen 50 mg/kg20 min after soman exposure
Model: Acute soman exposure at 1.2 x LD50 inducing status epilepticus and brain damage
LY293558 plus caramiphen terminated status epilepticus faster than LY293558 alone, prevented seizure return over 72 h of monitoring and spontaneous recurrent seizures at day 7, produced no detectable neurodegeneration, and body weight loss and recovery matched unexposed controls.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.