Reduction in Blood Glutamate Levels Combined With the Genetic Inactivation of A2AR Significantly Alleviate Traumatic Brain Injury-Induced Acute Lung Injury.
MouseTBIUnspecifiedMaleIntravenous administration of oxaloacetate; peritoneal dialysisAfter traumatic brain injury
Model: Mouse models of moderate and severe traumatic brain injury with secondary traumatic brain injury-induced acute lung injury
Raising blood glutamate worsened lung water content, lung-body index, bronchoalveolar inflammatory markers, lung injury score, incidence of acute lung injury and mortality, and lowered PaO2/FiO2, with further worsening when an A2AR activator was co-administered. Lowering blood glutamate by peritone…
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