Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization.

Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization.

Model: Acute respiratory distress syndrome induced by intratracheal lipopolysaccharide, with in vitro macrophage models using LPS or interferon-gamma

Nrf2 activation with tBHQ markedly reduced LPS-induced mortality and lung injury, down-regulated pro-inflammatory mediators and up-regulated anti-inflammatory mediators, consistent with a shift towards M2 macrophage polarisation.

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