18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.
MouseRadiationFemale
Model: Radiation-induced skin damage in mice, with irradiated RAW264.7 macrophages in vitro
18beta-Glycyrrhetinic acid reduced the severity of radiation-induced skin damage, inflammatory cell infiltration and cutaneous TNF-alpha, IL-1beta and IL-6, and in irradiated macrophages reduced IL-1beta, IL-6 and PGE2, p38 MAPK phosphorylation, AP-1 DNA binding, NF-kappaB activation and reactive o…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.