Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats.
RatChemical/toxinn = Untreated normal control group n = 6; group sizes for the m…Tail vein injection200 microlitres of phosphate-buffered saline containing hAM…4 hours after white smoke inhalation
Model: Lung injury induced by 5 minutes of white smoke inhalation from an ignited smoke pot in a purpose-built smoke exposure apparatus
hAMSCs localised mainly to lung tissue and progressively declined over 28 days. Compared with model and PBS groups, hAMSC treatment reduced the CT score, wet/dry weight ratio, histological lung injury score and lung fibrosis, increased PaO2 and PaO2/FiO2 and lowered PaCO2, increased SP-A, SP-C and…
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