Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact.
MouseTBIControlled cortical impactC57BL/6Malen = n = 6 for neurological severity score, rotarod, lesion volu…Intraperitoneal, dissolved in phosphate-buffered saline200 micrograms/kg30 min before the controlled cortical impact
Model: Moderate controlled cortical impact traumatic brain injury: 3.5 mm craniotomy over the right hemisphere 2.0 mm posterior to bregma and 2.0 mm lateral to the sagittal suture, 3 mm flat impactor tip, velocity 5.25 m/s, depth 2 mm, dwell time 100 ms, under isoflurane
Platonin at 200 micrograms/kg given intraperitoneally 30 min before controlled cortical impact improved neurological severity score, rotarod performance, 24 h locomotor hyperactivity and 48 h central zone time, while grip strength showed only a non-significant trend and body weight and mortality we…
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