Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins.
MixedOther
Model: Mouse model of acute respiratory distress syndrome; human acute bronchiolitis samples
Methyl-beta-cyclodextrin restored surfactant surface tension function to normal in both human bronchiolitis and ARDS mouse samples, and showed anti-inflammatory effects. Surfactant inhibition was attributed to elevated cholesterol and a cholesterol with oxidised phospholipid interaction.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.