Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal10 and 50 mg/kg
Model: Two models: thioacetamide-induced acute hepatotoxicity, and bile duct ligation as a chronic cholestatic liver injury model
Betaine at 10 and 50 mg/kg intraperitoneally reduced histopathological alterations, tissue markers of oxidative stress and serum biomarkers of hepatotoxicity in both the thioacetamide and bile duct ligation models. Betaine also protected hepatocyte mitochondria in both acute and chronic models, sug…
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