Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKbeta/NF-kappaB signaling pathway.
RatSpinal cord injuryContusionSprague-Dawley (per MeSH indexing)
Model: Acute contusion spinal cord injury in adult rats
MALAT1 was raised 2.4-fold at the contusion epicentre with IKKbeta/NF-kappaB activation and higher TNF-alpha and IL-1beta. MALAT1 knockdown improved hindlimb locomotor recovery and lowered TNF-alpha, IL-1beta and Iba-1 in injured cords.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.