Mesenchymal stem cells encapsulated into biomimetic hydrogel scaffold gradually release CCL2 chemokine in situ preserving cytoarchitecture and promoting functional recovery in spinal cord injury.
MouseSpinal cord injuryUnspecifiedC57BL/6 (per MeSH indexing)Local delivery to the lesioned spinal cord via hydrogel scaffold
Model: Traumatic spinal cord injury in rodent models
CCL2 secreted by MSCs and delivered from the hydrogel recruited macrophages and drove M2 conversion, prevented motor neuron degeneration in vitro and after spinal cord trauma in vivo, and significantly improved motor performance.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.