Topical Treatment of Skin Injury Inflicted in Mice by X-Ray Irradiation.
MouseRadiationSKH-HR2 hairlessFemaleTopical (cutaneous, dorsal skin)Applied in relation to the irradiation protocol; exact timing of first applicat…
Model: Dorsal skin irradiated with orthovoltage X-rays, total dose 4300 cGy delivered in 20 fractions over 1 month, to mimic human breast cancer radiotherapy skin injury
At 60 days after radiation, TEWL and hydration values remained abnormal and acute, chronic and granulomatous inflammation were present in all groups, with the severest damage in the deeper dermis. The treatment combination showed a comparatively beneficial effect on chronic and granulomatous inflam…
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