Pyruvate as a novel carrier of hydroxyethyl starch 130/0.4 may protect kidney in rats subjected to severe burns.
RatBurnUnspecifiedSprague-DawleyMalen = 140 rats total, randomly allocated into 7 groups of n=20 ea…Intravenous infusionHES130/0.4 infused at 18.75 mL/kg over 12 h, at a 1:1 ratio…Fluid resuscitation initiated after severe burn injury
Model: Lethal severe burn model in rats, followed by fluid resuscitation and assessment of burn-induced acute kidney injury
Pyruvate-enriched HES130/0.4 (group SP) and pyruvate saline (group PS) provided better renal preservation than corresponding normal-saline-carrier groups; group SP was significantly superior to group PS in renal surface blood flow, cystatin-C, NGAL, kidney water content and Paller histology scores…
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