Protective Effect of Scopoletin Against Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice.
MouseChemical/toxinSwiss miceMaleIntraperitoneal10 mg/kg1 hour after the first of six hourly cerulein injections (post-injury treatment)
Model: Cerulein-induced acute pancreatitis with associated lung injury
Scopoletin attenuated the severity of cerulein-induced acute pancreatitis and associated lung injury, reducing histological damage, myeloperoxidase activity, serum amylase, pancreatic and pulmonary proinflammatory cytokines, hydrogen sulfide and NF-kB activation, and mast cell activation markers, c…
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