Sesquiterpenoids from the root of Panax Ginseng protect CCl-induced acute liver injury by anti-inflammatory and anti-oxidative capabilities in mice.
MouseChemical/toxinICRMaleIntragastric2.5 and 10 mg/kg, dissolved in soybean oilSPG given for 7 days before CCl4 injection; CCl4 injected 1 hour after the end…
Model: Carbon tetrachloride (CCl4)-induced acute liver injury
SPG treatment at 2.5 and 10 mg/kg significantly reduced CCl4-induced elevations in serum AST and ALT, preserved normal liver architecture with no necrosis, restored antioxidant enzyme activities and reduced MDA, decreased proinflammatory cytokines, and reduced hepatic NF-kB p65, COX-2, MAPK p38, ER…
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