Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion.
MouseOtherC57BL/6 wild-type, Apoe-deficient and Ldlr-deficient mice; bone marrow chimeras reconstituted with wild-type or PAD4-deficient marrowMalen = n=8 carotid arteries per group for en face microscopy; othe…Soluble DNaseI or vehicle administered before induction of 6 hours of flow pert…
Model: Electrical current injury (3 W bipolar microcoagulator) of the left common carotid artery to tailor a neointima, followed 4 weeks later by a constrictive cuff producing local flow perturbation for 1 or 6 hours; separate atherogenesis studies used high fat diet for 5 or 10 weeks
PAD4 deficiency confined to bone marrow-derived cells did not alter fatty streak formation, plaque size, macrophage accumulation, smooth muscle cell area or collagen content after 5 or 10 weeks of atherogenic diet. In the flow perturbation model of superficial erosion, either haematopoietic PAD4 de…
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