Moringa oleifera standardised aqueous leaf extract-loaded hydrocolloid film dressing: in vivo dermal safety and wound healing evaluation in STZ/HFD diabetic rat model.
RatWoundSprague-DawleyMaleTopical film dressing applied to the woundFilms containing 0.1, 0.5 and 1% Moringa oleifera leaf extr…
Model: Full-thickness excision and partial-thickness abrasion wounds in streptozotocin plus high-fat-diet induced type 2 diabetic rats; acute dermal toxicity assessed separately in healthy rats over 14 days
The 0.5% film significantly accelerated wound closure (77.67 plus or minus 7.28% at day 7 in excision wounds and 81 plus or minus 4.5% in abrasion wounds versus control), with increased collagen deposition and complete re-epithelialisation at 0.5 and 1%, and no signs of dermal toxicity.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.