Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice.

Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice.

Model: Lipopolysaccharide-induced acute lung injury in mice, with parallel in vitro lipopolysaccharide-treated cell experiments

Treatment with the IGF-1 receptor monoclonal antibody lowered lavage cell counts and pro-inflammatory cytokines, reduced histological lung injury and decreased RIP3 and phosphorylated MLKL expression compared with non-treated animals.

Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.