Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis.
MouseHaemorrhage/shockUncontrolledC57BL/6 wild typeMalen = 8 mice per group as the powered target for the primary endp…Intravenous by tail vein injection30 mg/kg in a final infusion volume of 250 to 300 microlitr…30 minutes before laceration (pre-treatment) or 1 minute after laceration (resc…
Model: Uncontrolled intraperitoneal haemorrhage by liver laceration: midline laparotomy with laceration of 75% of the left middle lobe of the liver under sodium pentobarbital 70 mg/kg intraperitoneally, with femoral arterial cannulation for haemodynamic monitoring
Pre-treatment reduced blood loss (0.68 plus or minus 0.09 g versus 0.86 plus or minus 0.16 g for control particles and 0.84 plus or minus 0.13 g for saline, p less than 0.005) and prolonged time to hypotension, and rescue dosing also reduced blood loss although it produced no haemodynamic differenc…
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