Macrophage migration inhibitory factor antagonist (S,R)3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester attenuates inflammation and lung injury in rats with acute pancreatitis in pregnancy.
RatChemical/toxinSprague-DawleyFemale (pregnant)n = 18 pregnant rats in total, 6 per group across three groupsIntraperitoneal3.5 mg/kg in 5% dimethyl sulfoxide diluted in saline30 minutes before model induction
Model: Acute pancreatitis in pregnancy induced by retrograde infusion of 5% sodium taurocholate at 1 mL/kg into the biliary-pancreatic duct at 0.10 mL/min, with associated acute lung injury
ISO-1 reduced serum amylase and lipase, pancreatic and lung injury scores, serum cytokines, lung myeloperoxidase-positive cells, p38 phosphorylation and NF-kappaB nuclear translocation, without significantly changing MIF expression itself.
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