Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway.

Intra-arterial human urinary kallidinogenase alleviates brain injury in rats with permanent middle cerebral artery occlusion through PI3K/AKT/FoxO1 signaling pathway.

Model: Permanent middle cerebral artery occlusion in rats

Intra-arterial human urinary kallidinogenase improved neurological deficit scores, reduced infarct area, neurodegeneration and pro-inflammatory cytokines, raised IL-10 and reduced apoptosis markers, with the benefit abolished by PI3K inhibition.

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