TAK1 mediates excessive autophagy via p38 and ERK in cisplatin-induced acute kidney injury.
MouseChemical/toxinBALB/cMalen = 6 per group for in vivo endpoints; total animal number not…Intraperitoneal5Z-7-oxozeaenol 4 mg/kg; 3-methyladenine 20 mg/kg per day;…First injection 1 hour before cisplatin
Model: Cisplatin-induced acute kidney injury, with cisplatin dissolved in 0.9% saline at 1 mg/mL and given at 20 mg/kg by intraperitoneal injection, and animals killed 72 hours later
TAK1 inhibition lowered serum creatinine and urea nitrogen, reduced tubular damage, decreased LC3II and restored p62, and reduced p38 and ERK phosphorylation after cisplatin.
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