Therapeutic effects of Saussurea involucrata injection against severe acute pancreatitis-induced brain injury in rats.
RatChemical/toxinSprague-DawleyMale
Model: Severe acute pancreatitis induced by sodium taurocholate, with secondary brain injury
Treatment reduced mortality, serum amylase, endothelin-1 and nitric oxide contents, the endothelin-1 to nitric oxide ratio and pancreatic and brain pathological scores at 24 and 48 hours, and raised PI3K, Akt and endothelial nitric oxide synthase, with no effect in healthy animals.
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