Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3Kgamma/Akt inhibition.
MixedChemical/toxinWistar rats; BALB/c miceMale5 or 10 mg/kgAdministered after induction of acute pancreatitis (therapeutic administration)
Model: Three models of acute pancreatitis with associated acute lung injury: sodium taurocholate-induced acute pancreatitis in Wistar rats, caerulein-induced acute pancreatitis and palmitoleic acid plus ethanol-induced acute pancreatitis in BALB/c mice
Therapeutic dihydrodiosgenin reduced acinar necrosis and mitochondrial dysfunction, improved biochemical and histopathological indices in all three acute pancreatitis models via mitochondrial protection and PI3Kgamma/Akt inactivation, and lessened associated acute lung injury.
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