Anti-Semaphorin-7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury.
RatEndotoxin/LPSSprague-Dawley (specific pathogen free)Malen = 60 rats in total; two groups of n=20 each received Anti-SEM…Not explicitly stated; delivered to lung lesions via a hybrid nanometre liposome carrier10 mg/mL (volume not stated), delivered to lesions using a…Treatment initiated on day 3 after LPS injection
Model: Lipopolysaccharide-induced acute lung injury; LPS 500 ug/kg injected into the trachea via a 25-gauge needle under sodium pentobarbital anaesthesia
Anti-SEMA-7A reduced SEMA-7A and its receptor, lowered IL-1beta, IL-17A and TNF-alpha and the chemokines CXCR2, MIP-2 and KC, reduced neutrophil accumulation in the alveolar space and attenuated histological signs of LPS-induced acute lung injury.
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