Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Intranasal1 x 10 cells per animal (exponent not rendered in the retri…Postnatal day 12, three days after hypoxia-ischaemia; hypothermia given for 4 h…
Model: Neonatal hypoxia-ischaemia induced on postnatal day 9, followed by 4 h of therapeutic hypothermia
Mesenchymal stem cells and hypothermia each improved motor deficits, and only mesenchymal stem cells restored cognitive function. The combination produced worse long-term motor and cognitive deficits and exacerbated brain injury, with enhanced endothelial activation, peripheral immune cell infiltra…
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