VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats.
RatIschaemia-reperfusionRenalBrown-Norway donors, Lewis recipientsMalen = n = 6 per group in vivo; n = 8 in vitroIntravenousVEGF 10 mg/kg; comparator agents histone H3 10 or 50 mg/kg,…Given in association with transplantation; liver and blood harvested 24 h after…
Model: Brown-Norway to Lewis orthotopic renal allograft transplantation with 24 h cold ischaemia, causing remote liver injury
VEGF reduced hepatic caspase-1 and ASC expression, TUNEL positive cells, liver injury score, macrophage infiltration, IL-1 beta and IL-18, and lowered ALT and AST.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.