Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury.
RatChemical/toxinSprague-DawleyMalen = 48 rats randomised into two groups of 24 (PAK4 inhibitor, P…Intraperitoneal injection20 mg/kg/dayImmediately after each oral PAK4 inhibitor administration
Model: Gut mucosal barrier dysfunction and acute lung injury induced by oral administration of the PAK4 inhibitor PF-3758309 at 15 mg/kg/day
The PAK4 inhibitor reduced gut PAK4, ZO-1 and CD11c, raised plasma endotoxin, increased lung wet-to-dry ratio, alveolar wall thickness and circulating endothelial microparticles, and lowered lung PAK4 and CD11c. Simvastatin attenuated all of these changes, with alveolar wall thickness falling from…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.