PRECLINICAL PUBLICATION · 2018

Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Injury-site targeted complement inhibitors CR2-fH, CR2-Crry and CR2-CD59

PMID 29437855 ↗2018Mixed findings

Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.

MouseTBIControlled cortical impactC57BL/6MaleAcute administration after controlled cortical impact

Model: Controlled cortical impact traumatic brain injury

CR2-CD59 reduced acute deficits only, whereas CR2-Crry and CR2-fH improved chronic histological, cognitive and functional outcomes, indicating the alternative pathway drives chronic pathology.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.